.. meta::
   :description: Index of 19 published scientific papers by Laurence Loewe and collaborators — the peer-reviewed evidence behind the ResearchCity and Matheo paper claims.
   :keywords: ResearchCity, key papers, Laurence Loewe, evolutionary systems biology, Evolvix, population genetics, global computing, scientific publications, LLoL, MMv3
   :og:card:title: ResearchCity Key Papers<br>19 Published Scientific Papers
   :og:card:description: 19 peer-reviewed papers spanning 1991–2018 — from Jugend Forscht to the Annals of the New York Academy of Sciences. The scientific foundation behind ResearchCity.


.. include:: /_templates/include-file/page-prefix.rst


.. title:: Key Papers — 19 Publications


****************************************************************************************************
ResearchCity Key Papers — 19 Published Scientific Papers (1991--2018)
****************************************************************************************************

*The peer-reviewed scientific foundation behind the Matheo papers and ResearchCity claims — from age 17 to full professor.*


These 19 papers establish the scientific credentials behind the LLoL
project. The Matheo papers make claims rooted in evolutionary systems
biology, Evolvix, population genetics, and computational biology. This
collection provides the peer-reviewed evidence for readers who want to
check whether LLoL has the scientific background to make those claims.


Highlights
==========

- **Published in Science** (2003) — highest-impact journal in the collection
- **Framework-defining papers** — EvoSysBio (2009, 2012, 2016), Evolvix BEST Names (2017)
- **Directly relevant to Jubilee System** — Lazy Updating (2014) implies the core algorithm for Jubilee measuring
- **Directly relevant to POST system** — Evolvix BEST Names (2017) is the scientific foundation for naming conventions
- **35+ years of scientific work** — from Jugend Forscht (1991) to Complexity journal (2018)
- **Collaborations with leading scientists** — Brian Charlesworth, William G. Hill, Jane Hillston, and 34 co-authors on the Evolvix paper


All 19 papers (chronological)
==============================

.. list-table::
   :widths: 8 42 30 10 10
   :header-rows: 1

   * - Year
     - Title
     - Venue
     - Pages
     - Type
   * - 1991
     - :doc:`Electric Spark Productivity in Miller Experiments <loewe-1991-jugend-forscht>`
     - Jugend Forscht
     - 15
     - study
   * - 2002
     - :doc:`Evolutionary Bioinformatics — Dissertation <loewe-2002-diss>`
     - TU München (PhD thesis)
     - 444
     - diss
   * - 2002
     - :doc:`Global Computing for Bioinformatics <loewe-2002-global-computing>`
     - Briefings in Bioinformatics
     - 12
     - review
   * - 2003
     - :doc:`High Deleterious Mutation Rate in Stationary Phase E. coli <loewe-textor-scherer-2003>`
     - **Science** 302: 1558--1560
     - 17
     - study
   * - 2006
     - :doc:`Distribution of Mutational Effects in Drosophila <loewe-charlesworth-2006-dme>`
     - Biology Letters 2: 426--430
     - 6
     - study
   * - 2006
     - :doc:`Genomic Decay Paradox in Human mtDNA <loewe-2006-mullers-ratchet>`
     - Genetic Research 87: 133--159
     - 27
     - study
   * - 2007
     - :doc:`Background Selection in Single Genes <loewe-charlesworth-2007>`
     - Genetics 175: 1381--1393
     - 13
     - study
   * - 2007
     - :doc:`Evolution@home — Low-Effort Global Computing <loewe-2007-evolution-at-home>`
     - Software: Practice and Experience 37: 1289--1318
     - 30
     - study
   * - 2008
     - :doc:`DME in a Simple Circadian Clock <loewe-hillston-2008>`
     - LNBI 5307: 156--175 (CMSB 2008)
     - 20
     - study
   * - 2009
     - :doc:`A Framework for Evolutionary Systems Biology <loewe-2009-evosysbio-framework>`
     - BMC Systems Biology 3:27
     - 34
     - review
   * - 2009
     - :doc:`SBGN-PD Process Flow with Bio-PEPA <loewe-moodie-hillston-2009-eptcs>`
     - EPTCS 6: 93--107
     - 15
     - study
   * - 2009
     - :doc:`SBGNtext2BioPEPA Technical Report <loewe-moodie-hillston-2009-techreport>`
     - Edinburgh Tech Report EDI-INF-RR-1334
     - 29
     - techreport
   * - 2010
     - :doc:`Population Genetics of Mutations — Introduction <loewe-hill-2010>`
     - Phil. Trans. R. Soc. B 365: 1153--1167
     - 15
     - review
   * - 2012
     - :doc:`EvoSysBio, Adaptive Landscapes & DME <loewe-2012-evosysbio-landscapes>`
     - Adv. Exp. Med. Biol. 751: 399--
     - 12
     - review
   * - 2014
     - :doc:`Lazy Updating for Stochastic Simulations <ehlert-loewe-2014>`
     - J. Chem. Phys. 141: 204109
     - 20
     - study
   * - 2014
     - :doc:`Reproducibility in Large-Scale Computing <james-2014-reproducibility>`
     - XSEDE14 Workshop Report
     - 16
     - report
   * - 2016
     - :doc:`Systems in Evolutionary Systems Biology <loewe-2016-systems-evosysbio>`
     - Enc. Evol. Biol. 4: 297--318
     - 22
     - study
   * - 2017
     - :doc:`Evolvix BEST Names for Semantic Reproducibility <loewe-et-al-2017-evolvix>`
     - Ann. N.Y. Acad. Sci. 1387: 124--144
     - 95
     - study
   * - 2018
     - :doc:`Cooperation in a Two-Level Snowdrift Game <mcloone-et-al-2018>`
     - Complexity 2018: 9836150
     - 14
     - study


Key papers for the Matheo series
=================================

These papers are most directly relevant to claims made in the Matheo paper series:

- **Ehlert & Loewe 2014** — :doc:`Lazy Updating <ehlert-loewe-2014>` implies the core
  algorithm for Jubilee measuring (directly relevant to Jubilee System claims)
- **Loewe 2009, 2016** — :doc:`EvoSysBio framework <loewe-2009-evosysbio-framework>` and
  :doc:`encyclopedia entry <loewe-2016-systems-evosysbio>` (the scientific methodology behind modeling claims)
- **Loewe et al. 2017** — :doc:`Evolvix BEST Names <loewe-et-al-2017-evolvix>` (directly
  relevant to POST system and language design)
- **Loewe 2002** — :doc:`444-page dissertation <loewe-2002-diss>` (the deepest scientific root)
- **Loewe 1991** — :doc:`Jugend Forscht study <loewe-1991-jugend-forscht>` (earliest scientific work, age ~17)


.. toctree::
   :hidden:

   loewe-1991-jugend-forscht
   loewe-2002-diss
   loewe-2002-global-computing
   loewe-textor-scherer-2003
   loewe-charlesworth-2006-dme
   loewe-2006-mullers-ratchet
   loewe-charlesworth-2007
   loewe-2007-evolution-at-home
   loewe-hillston-2008
   loewe-2009-evosysbio-framework
   loewe-moodie-hillston-2009-eptcs
   loewe-moodie-hillston-2009-techreport
   loewe-hill-2010
   loewe-2012-evosysbio-landscapes
   ehlert-loewe-2014
   james-2014-reproducibility
   loewe-2016-systems-evosysbio
   loewe-et-al-2017-evolvix
   mcloone-et-al-2018
